Nav1.8 neurons are involved in limiting acute phase responses to dietary fat

• Autors principals: Swalpa Udit (Autor), Michael Burton (Autor), Joseph M. Rutkowski (Autor), Syann Lee (Autor), Angie L. Bookout (Autor), Philipp E. Scherer (Autor), Joel K. Elmquist (Autor), Laurent Gautron (Autor)
• Format: Llibre
• Publicat: Elsevier, 2017-10-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

Objective and methods: Metabolic viscera and their vasculature are richly innervated by peripheral sensory neurons. Here, we examined the metabolic and inflammatory profiles of mice with selective ablation of all Nav1.8-expressing primary afferent neurons. Results: While mice lacking sensory neurons...