Evaluation of pH-Sensitive Polymeric Micelles Using Citraconic Amide Bonds for the Co-Delivery of Paclitaxel, Etoposide, and Rapamycin

• Main Authors: Min Jeong Jo (Author), Hee Ji Shin (Author), Moon Sup Yoon (Author), Seo Yeon Kim (Author), Chae Eun Jin (Author), Chun-Woong Park (Author), Jin-Seok Kim (Author), Dae Hwan Shin (Author)
• Format: Book
• Published: MDPI AG, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Paclitaxel (PTX), etoposide (ETP), and rapamycin (RAPA) have different mechanisms, allowing multiple pathways to be targeted simultaneously, effectively treating various cancers. However, these drugs have a low hydrosolubility, limiting clinical applications. Therefore, we used pH-sensitive polymeri...