Sigma-1 Receptor Plays a Negative Modulation on N-type Calcium Channel

• Main Authors: Kang Zhang (Author), Zhe Zhao (Author), Liting Lan (Author), Xiaoli Wei (Author), Liyun Wang (Author), Xiaoyan Liu (Author), Haitao Yan (Author), Jianquan Zheng (Author)
• Format: Book
• Published: Frontiers Media S.A., 2017-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The sigma-1 receptor is a 223 amino acids molecular chaperone with a single transmembrane domain. It is resident to eukaryotic mitochondrial-associated endoplasmic reticulum and plasma membranes. By chaperone-mediated interactions with ion channels, G-protein coupled receptors and cell-signaling mol...