Discovery and Optimization of Selective Inhibitors of Meprin α (Part II)

• Main Authors: Chao Wang (Author), Juan Diez (Author), Hajeung Park (Author), Christoph Becker-Pauly (Author), Gregg B. Fields (Author), Timothy P. Spicer (Author), Louis D. Scampavia (Author), Dmitriy Minond (Author), Thomas D. Bannister (Author)
• Format: Book
• Published: MDPI AG, 2021-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Meprin α is a zinc metalloproteinase (metzincin) that has been implicated in multiple diseases, including fibrosis and cancers. It has proven difficult to find small molecules that are capable of selectively inhibiting meprin α, or its close relative meprin β, over numerous other metzincins which, i...