GPR35 antagonist CID-2745687 attenuates anchorage-independent cell growth by inhibiting YAP/TAZ activity in colorectal cancer cells

• Hoofdauteurs: Wuxiyar Otkur (Auteur), Xiaolong Liu (Auteur), Huan Chen (Auteur), Siyi Li (Auteur), Ting Ling (Auteur), Hanchen Lin (Auteur), Renyu Yang (Auteur), Tian Xia (Auteur), Huan Qi (Auteur), Hai-Long Piao (Auteur)
• Formaat: Boek
• Gepubliceerd in: Frontiers Media S.A., 2023-04-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Background and purpose: GPR35, a member of the orphan G-protein-coupled receptor, was recently implicated in colorectal cancer (CRC). However, whether targeting GPR35 by antagonists can inhibit its pro-cancer role has yet to be answered.Experimental approach: We applied antagonist CID-2745687 (CID)...