PBPK modeling to evaluate maximum tolerated doses: A case study with 3-chloroallyl alcohol
Introduction: A physiologically based pharmacokinetic (PBPK) model for 3-chloroallyl alcohol (3-CAA) was developed and used to evaluate the design of assays for the in vivo genotoxicity of 3-CAA.Methods: Model development was supported by read across from a published PBPK model for ethanol. Read acr...
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Frontiers Media S.A.,
2023-02-01T00:00:00Z.
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