PBPK modeling to evaluate maximum tolerated doses: A case study with 3-chloroallyl alcohol

• Main Authors: Rory P. Conolly (Author), Harvey J. Clewell (Author), Martha M. Moore (Author), Jerry L. Campbell (Author), Wanyun Cheng (Author), R. Robinan Gentry (Author)
• פורמט: ספר
• יצא לאור: Frontiers Media S.A., 2023-02-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

Introduction: A physiologically based pharmacokinetic (PBPK) model for 3-chloroallyl alcohol (3-CAA) was developed and used to evaluate the design of assays for the in vivo genotoxicity of 3-CAA.Methods: Model development was supported by read across from a published PBPK model for ethanol. Read acr...