BVR-A Deficiency Leads to Autophagy Impairment through the Dysregulation of AMPK/mTOR Axis in the Brain-Implications for Neurodegeneration

• Main Authors: Chiara Lanzillotta (Author), Ilaria Zuliani (Author), Chirag Vasavda (Author), Solomon H. Snyder (Author), Bindu D. Paul (Author), Marzia Perluigi (Author), Fabio Di Domenico (Author), Eugenio Barone (Author)
• Format: Book
• Published: MDPI AG, 2020-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Biliverdin reductase-A (BVR-A) impairment is associated with increased accumulation of oxidatively-damaged proteins along with the impairment of autophagy in the brain during neurodegenerative disorders. Reduced autophagy inhibits the clearance of misfolded proteins, which then form neurotoxic aggre...