BVR-A Deficiency Leads to Autophagy Impairment through the Dysregulation of AMPK/mTOR Axis in the Brain-Implications for Neurodegeneration

• Prif Awduron: Chiara Lanzillotta (Awdur), Ilaria Zuliani (Awdur), Chirag Vasavda (Awdur), Solomon H. Snyder (Awdur), Bindu D. Paul (Awdur), Marzia Perluigi (Awdur), Fabio Di Domenico (Awdur), Eugenio Barone (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: MDPI AG, 2020-07-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

Biliverdin reductase-A (BVR-A) impairment is associated with increased accumulation of oxidatively-damaged proteins along with the impairment of autophagy in the brain during neurodegenerative disorders. Reduced autophagy inhibits the clearance of misfolded proteins, which then form neurotoxic aggre...