Detection and quantitation of host cell proteins in monoclonal antibody drug products using automated sample preparation and data-independent acquisition LC-MS/MS

Detection and quantitation of host cell proteins in monoclonal antibody drug products using automated sample preparation and data-independent acquisition LC-MS/MS

Ensuring the removal of host cell proteins (HCPs) during downstream processing of recombinant proteins such as monoclonal antibodies (mAbs) remains a challenge. Since residual HCPs might affect product stability or safety, constant monitoring is required to demonstrate their removal to be below the...

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Main Authors: Lisa Strasser (Author), Giorgio Oliviero (Author), Craig Jakes (Author), Izabela Zaborowska (Author), Patrick Floris (Author), Meire Ribeiro da Silva (Author), Florian Füssl (Author), Sara Carillo (Author), Jonathan Bones (Author)
Format: Book
Published: Elsevier, 2021-12-01T00:00:00Z.
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