Detection and quantitation of host cell proteins in monoclonal antibody drug products using automated sample preparation and data-independent acquisition LC-MS/MS

• Autores principales: Lisa Strasser (Autor), Giorgio Oliviero (Autor), Craig Jakes (Autor), Izabela Zaborowska (Autor), Patrick Floris (Autor), Meire Ribeiro da Silva (Autor), Florian Füssl (Autor), Sara Carillo (Autor), Jonathan Bones (Autor)
• Formato: Libro
• Publicado: Elsevier, 2021-12-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Ensuring the removal of host cell proteins (HCPs) during downstream processing of recombinant proteins such as monoclonal antibodies (mAbs) remains a challenge. Since residual HCPs might affect product stability or safety, constant monitoring is required to demonstrate their removal to be below the...