Detection and quantitation of host cell proteins in monoclonal antibody drug products using automated sample preparation and data-independent acquisition LC-MS/MS

• Autori principali: Lisa Strasser (Autore), Giorgio Oliviero (Autore), Craig Jakes (Autore), Izabela Zaborowska (Autore), Patrick Floris (Autore), Meire Ribeiro da Silva (Autore), Florian Füssl (Autore), Sara Carillo (Autore), Jonathan Bones (Autore)
• Natura: Libro
• Pubblicazione: Elsevier, 2021-12-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Ensuring the removal of host cell proteins (HCPs) during downstream processing of recombinant proteins such as monoclonal antibodies (mAbs) remains a challenge. Since residual HCPs might affect product stability or safety, constant monitoring is required to demonstrate their removal to be below the...