Dual Role of Dietary Curcumin Through Attenuating AFB1-Induced Oxidative Stress and Liver Injury via Modulating Liver Phase-I and Phase-II Enzymes Involved in AFB1 Bioactivation and Detoxification

• Hoofdauteurs: Ishfaq Muhammad (Auteur), He Wang (Auteur), Xiaoqi Sun (Auteur), Xinghe Wang (Auteur), Meiyu Han (Auteur), Ziyin Lu (Auteur), Ping Cheng (Auteur), Muhammad A. Hussain (Auteur), Xiuying Zhang (Auteur)
• Formaat: Boek
• Gepubliceerd in: Frontiers Media S.A., 2018-05-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

It is well understood that liver cytochrome p450 enzymes are responsible for AFB1 bioactivation, while phase-II enzymes regulated by the transcription factor nuclear factor-erythroid-2-related factor 2 (Nrf2) are involved in detoxification of AFB1. In this study, we explored the potential of curcumi...