Dual Role of Dietary Curcumin Through Attenuating AFB1-Induced Oxidative Stress and Liver Injury via Modulating Liver Phase-I and Phase-II Enzymes Involved in AFB1 Bioactivation and Detoxification

• Main Authors: Ishfaq Muhammad (Author), He Wang (Author), Xiaoqi Sun (Author), Xinghe Wang (Author), Meiyu Han (Author), Ziyin Lu (Author), Ping Cheng (Author), Muhammad A. Hussain (Author), Xiuying Zhang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

It is well understood that liver cytochrome p450 enzymes are responsible for AFB1 bioactivation, while phase-II enzymes regulated by the transcription factor nuclear factor-erythroid-2-related factor 2 (Nrf2) are involved in detoxification of AFB1. In this study, we explored the potential of curcumi...