Type 1-skewed neuroinflammation and vascular damage associated with Orientia tsutsugamushi infection in mice.

• Auteurs principaux: Lynn Soong (Auteur), Thomas R Shelite (Auteur), Yan Xing (Auteur), Harica Kodakandla (Auteur), Yuejin Liang (Auteur), Brandon J Trent (Auteur), Paulina Horton (Auteur), Kathryn C Smith (Auteur), Zhenyang Zhao (Auteur), Jiaren Sun (Auteur), Donald H Bouyer (Auteur), Jiyang Cai (Auteur)
• Format: Livre
• Publié: Public Library of Science (PLoS), 2017-07-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

BACKGROUND:Scrub typhus is a life-threatening disease, due to infection with O. tsutsugamushi, a Gram-negative bacterium that preferentially replicates in endothelial cells and professional phagocytes. Meningoencephalitis has been reported in scrub typhus patients and experimentally-infected animals...