Type 1-skewed neuroinflammation and vascular damage associated with Orientia tsutsugamushi infection in mice.

• Main Authors: Lynn Soong (Author), Thomas R Shelite (Author), Yan Xing (Author), Harica Kodakandla (Author), Yuejin Liang (Author), Brandon J Trent (Author), Paulina Horton (Author), Kathryn C Smith (Author), Zhenyang Zhao (Author), Jiaren Sun (Author), Donald H Bouyer (Author), Jiyang Cai (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2017-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND:Scrub typhus is a life-threatening disease, due to infection with O. tsutsugamushi, a Gram-negative bacterium that preferentially replicates in endothelial cells and professional phagocytes. Meningoencephalitis has been reported in scrub typhus patients and experimentally-infected animals...