Development of dual GPBAR1 agonist and RORγt inverse agonist for the treatment of inflammatory bowel diseases
Inflammatory bowel diseases (IBD), including Crohn's disease and ulcerative colitis, are chronic disorders characterized by dysregulated immune response and persistent inflammation. Recent studies suggest that bile acid receptors, particularly GPBAR1, and the transcription factor RORγt play cri...
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Elsevier,
2024-10-01T00:00:00Z.
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