Development of dual GPBAR1 agonist and RORγt inverse agonist for the treatment of inflammatory bowel diseases

• Автори: Michele Biagioli (Автор), Cristina Di Giorgio (Автор), Elva Morretta (Автор), Rachele Bellini (Автор), Carmen Massa (Автор), Ginevra Urbani (Автор), Martina Bordoni (Автор), Silvia Marchianò (Автор), Ginevra Lachi (Автор), Valentina Sepe (Автор), Maria Chiara Monti (Автор), Eleonora Distrutti (Автор), Angela Zampella (Автор), Stefano Fiorucci (Автор)
• Формат: Книга
• Опубліковано: Elsevier, 2024-10-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Inflammatory bowel diseases (IBD), including Crohn's disease and ulcerative colitis, are chronic disorders characterized by dysregulated immune response and persistent inflammation. Recent studies suggest that bile acid receptors, particularly GPBAR1, and the transcription factor RORγt play cri...