Development of dual GPBAR1 agonist and RORγt inverse agonist for the treatment of inflammatory bowel diseases

• 主要な著者: Michele Biagioli (著者), Cristina Di Giorgio (著者), Elva Morretta (著者), Rachele Bellini (著者), Carmen Massa (著者), Ginevra Urbani (著者), Martina Bordoni (著者), Silvia Marchianò (著者), Ginevra Lachi (著者), Valentina Sepe (著者), Maria Chiara Monti (著者), Eleonora Distrutti (著者), Angela Zampella (著者), Stefano Fiorucci (著者)
• フォーマット: 図書
• 出版事項: Elsevier, 2024-10-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Inflammatory bowel diseases (IBD), including Crohn's disease and ulcerative colitis, are chronic disorders characterized by dysregulated immune response and persistent inflammation. Recent studies suggest that bile acid receptors, particularly GPBAR1, and the transcription factor RORγt play cri...