Self-assembling HA/PEI/dsRNA-p21 ternary complexes for CD44 mediated small active RNA delivery to colorectal cancer

• Main Authors: Chen-Lin Feng (Author), Yan-Xing Han (Author), Hui-Hui Guo (Author), Xiao-Lei Ma (Author), Zhi-Qiang Wang (Author), Lu-Lu Wang (Author), Wen-Sheng Zheng (Author), Jian-Dong Jiang (Author)
• Format: Book
• Published: Taylor & Francis Group, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Our previous work proved that sequence specific double strand RNA (dsRNA-p21) effectively activated p21 gene expression of colorectal cancer (CRC) cells and consequently suppressed CRC growth. However, efficient delivery system is a significant challenge to achieve sufficient therapy. In this study,...