Self-assembling HA/PEI/dsRNA-p21 ternary complexes for CD44 mediated small active RNA delivery to colorectal cancer

• Asıl Yazarlar: Chen-Lin Feng (Yazar), Yan-Xing Han (Yazar), Hui-Hui Guo (Yazar), Xiao-Lei Ma (Yazar), Zhi-Qiang Wang (Yazar), Lu-Lu Wang (Yazar), Wen-Sheng Zheng (Yazar), Jian-Dong Jiang (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Taylor & Francis Group, 2017-01-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Our previous work proved that sequence specific double strand RNA (dsRNA-p21) effectively activated p21 gene expression of colorectal cancer (CRC) cells and consequently suppressed CRC growth. However, efficient delivery system is a significant challenge to achieve sufficient therapy. In this study,...