Mutations in CCNB3 affect its location thus causing a multiplicity of phenotypes in human oocytes maturation by aberrant CDK1 activity and APC/C activity at different stages

• Main Authors: Congjing Wang (Author), Meng Xi Chen (Author), Yuan Zhang (Author), Xue Bai (Author), Qiqi Cao (Author), Jian Han (Author), Nana Zhang (Author), Chun Zhao (Author), Xiufeng Ling (Author), Ximan Rui (Author), Yichun Guan (Author), Junqiang Zhang (Author), Ran Huo (Author)
• Format: Book
• Published: BMC, 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Oocyte maturation arrest results in female infertility and the genetic etiology of this phenotype remains largely unknown. Previous studies have proven that cyclins play a significant role in the cell cycle both in meiosis and mitosis. Cyclin B3 (CCNB3) is one of the members of t...