Mutations in CCNB3 affect its location thus causing a multiplicity of phenotypes in human oocytes maturation by aberrant CDK1 activity and APC/C activity at different stages

• Автори: Congjing Wang (Автор), Meng Xi Chen (Автор), Yuan Zhang (Автор), Xue Bai (Автор), Qiqi Cao (Автор), Jian Han (Автор), Nana Zhang (Автор), Chun Zhao (Автор), Xiufeng Ling (Автор), Ximan Rui (Автор), Yichun Guan (Автор), Junqiang Zhang (Автор), Ran Huo (Автор)
• Формат: Книга
• Опубліковано: BMC, 2023-08-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Abstract Background Oocyte maturation arrest results in female infertility and the genetic etiology of this phenotype remains largely unknown. Previous studies have proven that cyclins play a significant role in the cell cycle both in meiosis and mitosis. Cyclin B3 (CCNB3) is one of the members of t...