Acid-Sensitive Sheddable PEGylated PLGA Nanoparticles Increase the Delivery of TNF-α siRNA in Chronic Inflammation Sites

• Main Authors: Abdulaziz M Aldayel (Author), Youssef W Naguib (Author), Hannah L O'Mary (Author), Xu Li (Author), Mengmeng Niu (Author), Tinashe B Ruwona (Author), Zhengrong Cui (Author)
• Format: Book
• Published: Elsevier, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

There has been growing interest in utilizing small interfering RNA (siRNA) specific to pro-inflammatory cytokines, such as tumor necrosis factor-α (TNF-α), in chronic inflammation therapy. However, delivery systems that can increase the distribution of the siRNA in chronic inflammation sites after i...