Acid-Sensitive Sheddable PEGylated PLGA Nanoparticles Increase the Delivery of TNF-α siRNA in Chronic Inflammation Sites

• Päätekijät: Abdulaziz M Aldayel (Tekijä), Youssef W Naguib (Tekijä), Hannah L O'Mary (Tekijä), Xu Li (Tekijä), Mengmeng Niu (Tekijä), Tinashe B Ruwona (Tekijä), Zhengrong Cui (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Elsevier, 2016-01-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

There has been growing interest in utilizing small interfering RNA (siRNA) specific to pro-inflammatory cytokines, such as tumor necrosis factor-α (TNF-α), in chronic inflammation therapy. However, delivery systems that can increase the distribution of the siRNA in chronic inflammation sites after i...