Crosstalk between TBK1/IKKε and the type I interferon pathway contributes to tubulointerstitial inflammation and kidney tubular injury

• Auteurs principaux: Gina Córdoba-David (Auteur), Jorge García-Giménez (Auteur), Regiane Cardoso Castelo-Branco (Auteur), Susana Carrasco (Auteur), Pablo Cannata (Auteur), Alberto Ortiz (Auteur), Adrián M. Ramos (Auteur)
• Format: Livre
• Publié: Frontiers Media S.A., 2022-09-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

The type I interferon (TI-IFN) pathway regulates innate immunity, inflammation, and apoptosis during infection. However, the contribution of the TI-IFN pathway or upstream signaling pathways to tubular injury in kidney disease is poorly understood. Upon observing evidence of activation of upstream r...