Crosstalk between TBK1/IKKε and the type I interferon pathway contributes to tubulointerstitial inflammation and kidney tubular injury

• Main Authors: Gina Córdoba-David (Author), Jorge García-Giménez (Author), Regiane Cardoso Castelo-Branco (Author), Susana Carrasco (Author), Pablo Cannata (Author), Alberto Ortiz (Author), Adrián M. Ramos (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The type I interferon (TI-IFN) pathway regulates innate immunity, inflammation, and apoptosis during infection. However, the contribution of the TI-IFN pathway or upstream signaling pathways to tubular injury in kidney disease is poorly understood. Upon observing evidence of activation of upstream r...