Carboranyl-1,8-naphthalimide intercalators induce lysosomal membrane permeabilization and ferroptosis in cancer cell lines

• Prif Awduron: Sebastian Rykowski (Awdur), Dorota Gurda-Woźna (Awdur), Agnieszka Fedoruk-Wyszomirska (Awdur), Marta Orlicka-Płocka (Awdur), Aleksandra Kowalczyk (Awdur), Paweł Stączek (Awdur), Marta Denel-Bobrowska (Awdur), Katarzyna Biniek-Antosiak (Awdur), Wojciech Rypniewski (Awdur), Eliza Wyszko (Awdur), Agnieszka B. Olejniczak (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

The synthesis of carborane-1,8-naphthalimide conjugates and evaluation of their DNA-binding ability and anticancer activity were performed. A series of 4-carboranyl-3-nitro-1,8-naphthalimide derivatives, mitonafide and pinafide analogs, were synthesised via amidation and reductive amination reaction...