Discovery and confirmation of ligand binding specificities of the Schistosoma japonicum polarity protein Scribble.

• Hlavní autoři: Pengfei Cai (Autor), Yi Mu (Autor), Xianyu Piao (Autor), Nan Hou (Autor), Shuai Liu (Autor), Youhe Gao (Autor), Heng Wang (Autor), Qijun Chen (Autor)
• Médium: Kniha
• Vydáno: Public Library of Science (PLoS), 2014-05-01T00:00:00Z.
• Témata: article
• On-line přístup: Connect to this object online.

BACKGROUND: Schistosomiasis is a chronic debilitating parasitic disease that afflicts more than 200 million individuals worldwide. Long-term administration of chemotherapy with the single available drug, praziquantel, has led to growing concerns about drug resistance. The PSD-95/Dlg/ZO-1 (PDZ) domai...