Discovery and confirmation of ligand binding specificities of the Schistosoma japonicum polarity protein Scribble.

• Hoofdauteurs: Pengfei Cai (Auteur), Yi Mu (Auteur), Xianyu Piao (Auteur), Nan Hou (Auteur), Shuai Liu (Auteur), Youhe Gao (Auteur), Heng Wang (Auteur), Qijun Chen (Auteur)
• Formaat: Boek
• Gepubliceerd in: Public Library of Science (PLoS), 2014-05-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

BACKGROUND: Schistosomiasis is a chronic debilitating parasitic disease that afflicts more than 200 million individuals worldwide. Long-term administration of chemotherapy with the single available drug, praziquantel, has led to growing concerns about drug resistance. The PSD-95/Dlg/ZO-1 (PDZ) domai...