Discovery and confirmation of ligand binding specificities of the Schistosoma japonicum polarity protein Scribble.

• Main Authors: Pengfei Cai (Author), Yi Mu (Author), Xianyu Piao (Author), Nan Hou (Author), Shuai Liu (Author), Youhe Gao (Author), Heng Wang (Author), Qijun Chen (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2014-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND: Schistosomiasis is a chronic debilitating parasitic disease that afflicts more than 200 million individuals worldwide. Long-term administration of chemotherapy with the single available drug, praziquantel, has led to growing concerns about drug resistance. The PSD-95/Dlg/ZO-1 (PDZ) domai...