Model‐based simulation to support the approval of isatuximab alone or with dexamethasone for the treatment of relapsed/refractory multiple myeloma in Japanese patients

• Главные авторы: Hoai‐Thu Thai (Автор), Kimiko Koiwai (Автор), Yoshihisa Shitara (Автор), Hirotaka Kazama (Автор), Jean‐Baptiste Fau (Автор), Dorothée Semiond (Автор), Christine Veyrat‐Follet (Автор)
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• Опубликовано: Wiley, 2023-12-01T00:00:00Z.
• Предметы: article
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Abstract This study aimed to support dosing regimen selection for isatuximab as a single agent or in combination with dexamethasone for Japanese patients with relapsed/refractory multiple myeloma (RRMM). A joint model characterizing the dynamics of serum M‐protein kinetics and its association with p...