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Central nervous system involvement in acute lymphoblastic leukemia: diagnosis by immunophenotyping

The central nervous system is the most commonly affected extramedullary site in acute lymphoblastic leukemia. Although morphologic evaluation of the cerebrospinal fluid has been traditionally used for diagnosing central nervous system involvement, it is a method of low sensitivity. The present study...

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Main Authors: Camila Silva Peres Cancela (Author), Mitiko Murao (Author), Marcelo Eduardo de Lima Souza (Author), José Márcio Barcelos (Author), Vírginia Miguel Furtado (Author), Maria Luiza Silva (Author), Marcos Borato Viana (Author), Benigna Maria de Oliveira (Author)
Format: Book
Published: Sociedade Brasileira de Patologia Clínica, 2013-08-01T00:00:00Z.
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Summary:The central nervous system is the most commonly affected extramedullary site in acute lymphoblastic leukemia. Although morphologic evaluation of the cerebrospinal fluid has been traditionally used for diagnosing central nervous system involvement, it is a method of low sensitivity. The present study aimed at evaluating the use of immunophenotyping in the detection of blasts in the cerebrospinal fluid from children and adolescents with acute lymphoblastic leukemia.
Item Description:1678-4774
10.1590/S1676-24442013000400005

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