Adhesins of Leptospira interrogans mediate the interaction to fibrinogen and inhibit fibrin clot formation in vitro.

Adhesins of Leptospira interrogans mediate the interaction to fibrinogen and inhibit fibrin clot formation in vitro.

We report in this work that Leptospira strains, virulent L. interrogans serovar Copenhageni, attenuated L. interrogans serovar Copenhageni and saprophytic L. biflexa serovar Patoc are capable of binding fibrinogen (Fg). The interaction of leptospires with Fg inhibits thrombin- induced fibrin clot fo...

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Main Authors: Rosane Oliveira (Author), Renan F Domingos (Author), Gabriela H Siqueira (Author), Luis G Fernandes (Author), Natalie M Souza (Author), Monica L Vieira (Author), Zenaide M de Morais (Author), Silvio A Vasconcellos (Author), Ana L T O Nascimento (Author)
Format: Book
Published: Public Library of Science (PLoS), 2013-01-01T00:00:00Z.
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