Adhesins of Leptospira interrogans mediate the interaction to fibrinogen and inhibit fibrin clot formation in vitro.

• Autori principali: Rosane Oliveira (Autore), Renan F Domingos (Autore), Gabriela H Siqueira (Autore), Luis G Fernandes (Autore), Natalie M Souza (Autore), Monica L Vieira (Autore), Zenaide M de Morais (Autore), Silvio A Vasconcellos (Autore), Ana L T O Nascimento (Autore)
• Natura: Libro
• Pubblicazione: Public Library of Science (PLoS), 2013-01-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

We report in this work that Leptospira strains, virulent L. interrogans serovar Copenhageni, attenuated L. interrogans serovar Copenhageni and saprophytic L. biflexa serovar Patoc are capable of binding fibrinogen (Fg). The interaction of leptospires with Fg inhibits thrombin- induced fibrin clot fo...