Dietary ω-3 Fatty Acid Supplementation Improves Murine Sickle Cell Bone Disease and Reprograms Adipogenesis

• Main Authors: Maria Teresa Valenti (Author), Alessandro Mattè (Author), Enrica Federti (Author), Mark Puder (Author), Lorenzo Anez-Bustillos (Author), Michela Deiana (Author), Samuele Cheri (Author), Arianna Minoia (Author), Carlo Brugnara (Author), Maria Luisa Di Paolo (Author), Luca Dalle Carbonare (Author), Lucia De Franceschi (Author)
• Format: Book
• Published: MDPI AG, 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Sickle cell disease (SCD) is a genetic disorder of hemoglobin, leading to chronic hemolytic anemia and multiple organ damage. Among chronic organ complications, sickle cell bone disease (SBD) has a very high prevalence, resulting in long-term disability, chronic pain and fractures. Here, we evaluate...