Sal003 alleviated intervertebral disc degeneration by inhibiting apoptosis and extracellular matrix degradation through suppressing endoplasmic reticulum stress pathway in rats

• Główni autorzy: Yan Chen (Autor), Baixing Li (Autor), Yue Xu (Autor), Tangjun Zhou (Autor), Changqing Zhao (Autor), Jie Zhao (Autor)
• Format: Książka
• Wydane: Frontiers Media S.A., 2023-01-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Apoptosis and extracellular matrix degradation of the nucleus pulposus are the main initiators of intervertebral disc degeneration (IVDD) and can be explained by endoplasmic reticulum (ER) stress. Thus, pharmacological therapy aimed at suppressing this pathway may be a promising approach for the man...