Anti-Inflammatory Activity of Kurarinone Involves Induction of HO-1 via the KEAP1/Nrf2 Pathway

• Main Authors: Sakiko Nishikawa (Author), Yasumichi Inoue (Author), Yuka Hori (Author), Chiharu Miyajima (Author), Daisuke Morishita (Author), Nobumichi Ohoka (Author), Shigeaki Hida (Author), Toshiaki Makino (Author), Hidetoshi Hayashi (Author)
• Format: Book
• Published: MDPI AG, 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Kurarinone, a flavonoid isolated from the roots of <i>Sophora flavescens</i>, was suggested to exert potent antioxidant and immunosuppressive effects. However, the underlying mechanisms remain unclear. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a key transcription factor that...