Antitumor Effect of Fluoxetine on Chronic Stress-Promoted Lung Cancer Growth via Suppressing Kynurenine Pathway and Enhancing Cellular Immunity

• Main Authors: Zhen Yang (Author), Zhuman Li (Author), Zhijun Guo (Author), Yu Ren (Author), Ting Zhou (Author), Zhijun Xiao (Author), Jingjing Duan (Author), Chuangchuang Han (Author), Yuanchi Cheng (Author), Feng Xu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Chronic stress promotes cancer growth. Antidepressant fluoxetine (FLX) is usually prescribed for cancer patients with comorbid depression. FLX displays inhibition on cancer cell proliferation, however, the in vivo activity has not been investigated.Methods: We explored the antitumor effe...