The gut microbiota as a modulator of innate immunity during melioidosis.

• Main Authors: Jacqueline M Lankelma (Author), Emma Birnie (Author), Tassili A F Weehuizen (Author), Brendon P Scicluna (Author), Clara Belzer (Author), Riekelt H Houtkooper (Author), Joris J T H Roelofs (Author), Alex F de Vos (Author), Tom van der Poll (Author), Andries E Budding (Author), W Joost Wiersinga (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2017-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND:Melioidosis, caused by the Gram-negative bacterium Burkholderia pseudomallei, is an emerging cause of pneumonia-derived sepsis in the tropics. The gut microbiota supports local mucosal immunity and is increasingly recognized as a protective mediator in host defenses against systemic infec...