Effects of Anti-TNFα Treatment on Mucosal Expression of IL-17A, IL-21, and IL-22 and Cytokine-Producing T Cell Subsets in Crohn's Disease

• Main Authors: Anders Dige (Author), Maria K. Magnusson (Author), Claus Uhrenholt (Author), Tue Kruse Rasmussen (Author), Tue Kragstrup (Author), Lena Öhman (Author), Jens Dahlerup (Author), Jørgen Agnholt (Author)
• Format: Bog
• Udgivet: Hindawi Limited, 2018-01-01T00:00:00Z.
• Fag: article
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T helper 17 (Th17) cells produce interleukin (IL) 17-A. In addition, Th17 cells produce IL-21 and IL-22. Th17 cells have a disease-promoting role in Crohn's disease (CD). We investigated the effects of anti-TNFα treatment on mucosal gene expression (qPCR) of IL-17A, IL-21, and IL-22 as well as...