c-MYC-mediated TRIB3/P62+ aggresomes accumulation triggers paraptosis upon the combination of everolimus and ginsenoside Rh2

The mammalian target of rapamycin (mTOR) pathway is abnormally activated in lung cancer. However, the anti-lung cancer effect of mTOR inhibitors as monotherapy is modest. Here, we identified that ginsenoside Rh2, an active component of Panax ginseng C. A. Mey., enhanced the anti-cancer effect of the...

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Main Authors: Min-Xia Su (Author), Yu-Lian Xu (Author), Xiao-Ming Jiang (Author), Mu-Yang Huang (Author), Le-Le Zhang (Author), Luo-Wei Yuan (Author), Xiao-Huang Xu (Author), Qi Zhu (Author), Jian-Li Gao (Author), Jia-Hong Lu (Author), Xiuping Chen (Author), Ming-Qing Huang (Author), Yitao Wang (Author), Jin-Jian Lu (Author)
Format: Book
Published: Elsevier, 2022-03-01T00:00:00Z.
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