c-MYC-mediated TRIB3/P62+ aggresomes accumulation triggers paraptosis upon the combination of everolimus and ginsenoside Rh2

• Päätekijät: Min-Xia Su (Tekijä), Yu-Lian Xu (Tekijä), Xiao-Ming Jiang (Tekijä), Mu-Yang Huang (Tekijä), Le-Le Zhang (Tekijä), Luo-Wei Yuan (Tekijä), Xiao-Huang Xu (Tekijä), Qi Zhu (Tekijä), Jian-Li Gao (Tekijä), Jia-Hong Lu (Tekijä), Xiuping Chen (Tekijä), Ming-Qing Huang (Tekijä), Yitao Wang (Tekijä), Jin-Jian Lu (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Elsevier, 2022-03-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

The mammalian target of rapamycin (mTOR) pathway is abnormally activated in lung cancer. However, the anti-lung cancer effect of mTOR inhibitors as monotherapy is modest. Here, we identified that ginsenoside Rh2, an active component of Panax ginseng C. A. Mey., enhanced the anti-cancer effect of the...