Heme in pathophysiology: a matter of scavenging, metabolism and trafficking across cell membranes

• Hoofdauteurs: Deborah eChiabrando (Auteur), Francesca eVinchi (Auteur), Veronica eFiorito (Auteur), Sonia eMercurio (Auteur), Emanuela eTolosano (Auteur)
• Formaat: Boek
• Gepubliceerd in: Frontiers Media S.A., 2014-04-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Heme (iron-protoporphyrin IX) is an essential co-factor involved in multiple biological processes: oxygen transport and storage, electron transfer, drug and steroid metabolism, signal transduction, and micro RNA processing. However, excess free-heme is highly toxic due to its ability to promote oxid...