Heme in pathophysiology: a matter of scavenging, metabolism and trafficking across cell membranes

• Main Authors: Deborah eChiabrando (Author), Francesca eVinchi (Author), Veronica eFiorito (Author), Sonia eMercurio (Author), Emanuela eTolosano (Author)
• Format: Book
• Published: Frontiers Media S.A., 2014-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Heme (iron-protoporphyrin IX) is an essential co-factor involved in multiple biological processes: oxygen transport and storage, electron transfer, drug and steroid metabolism, signal transduction, and micro RNA processing. However, excess free-heme is highly toxic due to its ability to promote oxid...