Heme in pathophysiology: a matter of scavenging, metabolism and trafficking across cell membranes

• Glavni autori: Deborah eChiabrando (Autor), Francesca eVinchi (Autor), Veronica eFiorito (Autor), Sonia eMercurio (Autor), Emanuela eTolosano (Autor)
• Format: Knjiga
• Izdano: Frontiers Media S.A., 2014-04-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Heme (iron-protoporphyrin IX) is an essential co-factor involved in multiple biological processes: oxygen transport and storage, electron transfer, drug and steroid metabolism, signal transduction, and micro RNA processing. However, excess free-heme is highly toxic due to its ability to promote oxid...