β-Tocotrienol Decreases PDGF-BB-Induced Proliferation and Migration of Human Airway Smooth Muscle Cells by Inhibiting RhoA and Reducing ROS Production

• Main Authors: Aditya Sri Listyoko (Author), Ryota Okazaki (Author), Tomoya Harada (Author), Miki Takata (Author), Masato Morita (Author), Hiroki Ishikawa (Author), Yoshihiro Funaki (Author), Akira Yamasaki (Author)
• Format: Book
• Published: MDPI AG, 2024-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Tocotrienols exhibit antioxidant and anti-inflammatory activities. RhoA, a small GTPase protein, plays a crucial role in regulating contractility in airway smooth muscle (ASM). Previous studies have demonstrated that γ-tocotrienols reduce ASM proliferation and migration by inhibiting the...