The importance of targeting signalling mechanisms of the SLC39A family of zinc transporters to inhibit endocrine resistant breast cancer

• Päätekijät: Samuel Jones (Tekijä), Georgia Farr (Tekijä), Thirayost Nimmanon (Tekijä), Silvia Ziliotto (Tekijä), Julia M.W. Gee (Tekijä), Kathryn M. Taylor (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Open Exploration Publishing Inc., 2022-04-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Aim: Zinc is a key secondary messenger that can regulate multiple signalling pathways within cancer cells, thus its levels need to be strictly controlled. The Zrt, Irt-like protein (ZIP, SLC39A) family of zinc transporters increase cytosolic zinc from either extracellular or intracellular stores. Th...