The importance of targeting signalling mechanisms of the SLC39A family of zinc transporters to inhibit endocrine resistant breast cancer

• Κύριοι συγγραφείς: Samuel Jones (Συγγραφέας), Georgia Farr (Συγγραφέας), Thirayost Nimmanon (Συγγραφέας), Silvia Ziliotto (Συγγραφέας), Julia M.W. Gee (Συγγραφέας), Kathryn M. Taylor (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: Open Exploration Publishing Inc., 2022-04-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

Aim: Zinc is a key secondary messenger that can regulate multiple signalling pathways within cancer cells, thus its levels need to be strictly controlled. The Zrt, Irt-like protein (ZIP, SLC39A) family of zinc transporters increase cytosolic zinc from either extracellular or intracellular stores. Th...