Endogenous GABA Does Not Mediate the Inhibitory Effects of Gabapentin on Spinal Reflexes in Rats

• 主要な著者: Shinobu Shimizu (著者), Motoko Honda (著者), Mitsuo Tanabe (著者), Jun-Ichiro Oka (著者), Hideki Ono (著者)
• フォーマット: 図書
• 出版事項: Elsevier, 2004-01-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

The novel antiepileptic drug gabapentin was designed as a structural analog of γ-aminobutyric acid (GABA). However, its mechanism of action remains unclear. In the present study, we investigated the effect of gabapentin on spinal reflexes in anesthetized rats. The mono- and polysynaptic reflex poten...