Endogenous GABA Does Not Mediate the Inhibitory Effects of Gabapentin on Spinal Reflexes in Rats

• Główni autorzy: Shinobu Shimizu (Autor), Motoko Honda (Autor), Mitsuo Tanabe (Autor), Jun-Ichiro Oka (Autor), Hideki Ono (Autor)
• Format: Książka
• Wydane: Elsevier, 2004-01-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

The novel antiepileptic drug gabapentin was designed as a structural analog of γ-aminobutyric acid (GABA). However, its mechanism of action remains unclear. In the present study, we investigated the effect of gabapentin on spinal reflexes in anesthetized rats. The mono- and polysynaptic reflex poten...