Inflammation as a Possible Trigger for Mitoxantrone-Induced Cardiotoxicity: An In Vivo Study in Adult and Infant Mice

• المؤلفون الرئيسيون: Ana Reis-Mendes (مؤلف), José Luís Dores-Sousa (مؤلف), Ana Isabel Padrão (مؤلف), Margarida Duarte-Araújo (مؤلف), José Alberto Duarte (مؤلف), Vítor Seabra (مؤلف), Salomé Gonçalves-Monteiro (مؤلف), Fernando Remião (مؤلف), Félix Carvalho (مؤلف), Emília Sousa (مؤلف), Maria Lourdes Bastos (مؤلف), Vera Marisa Costa (مؤلف)
• التنسيق: كتاب
• منشور في: MDPI AG, 2021-05-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Mitoxantrone (MTX) is a pharmaceutical drug used in the treatment of several cancers and refractory multiple sclerosis (MS). Despite its therapeutic value, adverse effects may be severe, namely the frequently reported cardiotoxicity, whose mechanisms need further research. This work aimed to assess...