Inflammation as a Possible Trigger for Mitoxantrone-Induced Cardiotoxicity: An In Vivo Study in Adult and Infant Mice

• Main Authors: Ana Reis-Mendes (Author), José Luís Dores-Sousa (Author), Ana Isabel Padrão (Author), Margarida Duarte-Araújo (Author), José Alberto Duarte (Author), Vítor Seabra (Author), Salomé Gonçalves-Monteiro (Author), Fernando Remião (Author), Félix Carvalho (Author), Emília Sousa (Author), Maria Lourdes Bastos (Author), Vera Marisa Costa (Author)
• Format: Book
• Published: MDPI AG, 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mitoxantrone (MTX) is a pharmaceutical drug used in the treatment of several cancers and refractory multiple sclerosis (MS). Despite its therapeutic value, adverse effects may be severe, namely the frequently reported cardiotoxicity, whose mechanisms need further research. This work aimed to assess...