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Engineering RsDddA as mitochondrial base editor with wide target compatibility and enhanced activity

Double-stranded DNA-specific cytidine deaminase (DddA) base editors hold great promise for applications in bio-medical research, medicine, and biotechnology. Strict sequence preference on spacing region presents a challenge for DddA editors to reach their full potential. To overcome this sequence-co...

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Bibliographic Details
Main Authors: Kai Cheng (Author), Cao Li (Author), Jiachuan Jin (Author), Xuezhen Qian (Author), Jiayin Guo (Author), Limini Shen (Author), YiChen Dai (Author), Xue Zhang (Author), Zhanwei Li (Author), Yichun Guan (Author), Fei Zhou (Author), Jin Tang (Author), Jun Zhang (Author), Bin Shen (Author), Xin Lou (Author)
Format: Book
Published: Elsevier, 2023-12-01T00:00:00Z.
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