Magnetically Assisted Drug Delivery of Topical Eye Drops Maintains Retinal Function In Vivo in Mice

• Main Authors: Marco Bassetto (Author), Daniel Ajoy (Author), Florent Poulhes (Author), Cathy Obringer (Author), Aurelie Walter (Author), Nadia Messadeq (Author), Amir Sadeghi (Author), Jooseppi Puranen (Author), Marika Ruponen (Author), Mikko Kettunen (Author), Elisa Toropainen (Author), Arto Urtti (Author), Hélène Dollfus (Author), Olivier Zelphati (Author), Vincent Marion (Author)
• Format: Book
• Published: MDPI AG, 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Barded-Biedl syndrome (BBS) is a rare genetic disorder with an unmet medical need for retinal degeneration. Small-molecule drugs were previously identified to slow down the apoptosis of photoreceptors in BBS mouse models. Clinical translation was not practical due to the necessity of repetitive inva...