A target repurposing approach identifies N-myristoyltransferase as a new candidate drug target in filarial nematodes.

• Main Authors: Brendan D Galvin (Author), Zhiru Li (Author), Estelle Villemaine (Author), Catherine B Poole (Author), Melissa S Chapman (Author), Michael P Pollastri (Author), Paul G Wyatt (Author), Clotilde K S Carlow (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2014-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Myristoylation is a lipid modification involving the addition of a 14-carbon unsaturated fatty acid, myristic acid, to the N-terminal glycine of a subset of proteins, a modification that promotes their binding to cell membranes for varied biological functions. The process is catalyzed by myristoyl-C...