A target repurposing approach identifies N-myristoyltransferase as a new candidate drug target in filarial nematodes.

• Главные авторы: Brendan D Galvin (Автор), Zhiru Li (Автор), Estelle Villemaine (Автор), Catherine B Poole (Автор), Melissa S Chapman (Автор), Michael P Pollastri (Автор), Paul G Wyatt (Автор), Clotilde K S Carlow (Автор)
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• Опубликовано: Public Library of Science (PLoS), 2014-09-01T00:00:00Z.
• Предметы: article
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Myristoylation is a lipid modification involving the addition of a 14-carbon unsaturated fatty acid, myristic acid, to the N-terminal glycine of a subset of proteins, a modification that promotes their binding to cell membranes for varied biological functions. The process is catalyzed by myristoyl-C...